There are various factors to take into consideration when making this decision. First of all, we want to provide you with a formulation that allows you to get the most medication with the lowest and most convenient dosing. It is important to be involved in the decision making process with both your physician and your compounding pharmacist. An advantage to utilizing capsules is that they can be made into sustained release formulations, which allow patients to take them only once daily. When considering topical formulations, sublingual troches, injections, and suppositories , the bio-identical hormones can bypass the patient's digestive system, and allow a lower does to utilized because the hormones are now being broken down by the acid in the stomach.